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Why do mothers with type O blood have the greatest risk of having children?

Pregnancy is a very hard thing, but for those mothers with special blood type, there is a great danger. It is said that mothers with type O blood are at great risk of having children, because children born to mothers with type O blood and fathers who are not with type O blood may cause 'neonatal ABO hemolysis' due to blood type incompatibility with their mothers.

When it comes to ABO hemolysis of newborn, we first need to talk about the genetic law of blood type and look at this table!

For example, if the mother is type O and the father is type A, the child may be type A or type O. if the mother is type O and the father is type AB, the child must be type A or type B.

Then we talk about hemolysis of the newborn. Back to the example above, if the mother's O-type and father's AB type, the baby is certainly not O-type blood, maybe A-type or B-type blood, it will stimulate the mother's body to produce a special anti-A or anti-B antibody, which can return to the fetus through the placenta, destroy the red blood cells of the fetus, and cause hemolysis of the fetus.

In addition to hemolysis of newborn caused by ABO blood group incompatibility and hemolysis caused by Rh blood group incompatibility, the truth is the same. If the mother is Rh negative blood (the legendary panda blood) but the father is RH positive blood, the fetus is likely to be RH positive blood, then it will also stimulate the mother to produce anti RH antibody, which can also enter the fetus to cause hemolysis, but because R H antigen is highly specific and only exists on RH positive red blood cells. Expectant mothers of Rh negative blood who are pregnant for the first time seldom suffer from hemolysis due to insufficient antibodies. To sum up, mothers of panda blood (RH negative blood) have a very low probability of hemolysis in the first birth, a high probability of second birth and a serious condition once it occurs.

Therefore, if there is a possibility of maternal fetal blood group incompatibility (mom o or Rh negative, but dad is not), it is necessary to regularly take blood samples to determine the ABO and Rh antibody titers in the blood of pregnant women. At 28-32 weeks of gestation, it was measured once every two weeks, and once a week after 32 weeks. Most children with ABO blood group incompatibility can be cured. Serious can appear pathological icterus, need medicine or blue light treatment.

Of course! It's not to say that "blood type incompatibility" means that you can't get married and have children. In fact, even if the blood type of husband and wife is different, the chance of hemolysis of newborn is only 2% - 2.5%. It's just that the parents to be checked should do a good job. Once hemolysis of newborn occurs, they should intervene and treat as soon as possible, which is very safe. If the mother to be with RH negative blood wants to have a second child, she must inject anti D immunoglobulin within 72 hours after giving birth to the first child to prevent the production of antibodies and reduce the risk of hemolysis of the second child. In short, follow the doctor's advice, relax! Don't be too afraid, and don't care about anything!