Why can't we eat cephalosporin? What are the consequences of drinking after eating cephalosporin
Four seas network: some time ago, there was a paragraph on the Internet that said: cephalosporin wine, go away. We know that when we eat cephalosporin, we can't drink. When we see a doctor in a hospital, doctors also care about whether patients drink alcohol. Why can't we drink when we eat cephalosporin? What are the consequences of drinking cephalosporin? Let's have a look.
After alcohol enters the human body, it needs to be oxidized and metabolized by two enzymes. Firstly, it is oxidized to acetaldehyde by alcohol dehydrogenase, and then acetaldehyde is oxidized to water by acetaldehyde dehydrogenase. Research and analysis: when cephalosporin drugs are combined with alcohol, it is easy to produce 'disulfiram' reaction. In short, cephalosporin drugs inhibit acetaldehyde dehydrogenase in the liver. This enzyme is very important for people who drink alcohol. A high level of enzyme means that it has a strong anti alcohol function. Once the function of the enzyme is inhibited, alcohol (ethanol) can no longer be oxidized and decomposed after being oxidized into acetaldehyde in the human body, which leads to the accumulation of acetaldehyde in the body and the acetaldehyde poisoning reaction. Clinical research has found that the reaction generally occurs 8 to 10 minutes after drinking, sometimes only 20 seconds later, and the slowest 1 hour later. The severity of the reaction is directly proportional to the amount of drugs and alcohol consumption. If the person who does not drink or has a small amount of alcohol, the reaction is more serious. The reaction after intravenous administration is faster and more serious than oral administration. The main manifestations are facial fever, flushing, blurred vision, headache, nausea and vomiting, tachycardia, hypotension, restlessness, etc.
For the symptoms of disulfiram reaction, if they appear quickly, they will be relieved and disappear quickly, and they can be relieved by themselves after general rest adjustment; if serious symptoms such as respiratory depression, myocardial infarction, and acute heart failure occur, they must be immediately sent to the hospital for symptomatic treatment, and promote ethanol metabolism and excretion as soon as possible. If they are not treated in time, they may lead to shock or even death.
A person who drinks a kilo of alcohol can have serious problems, including death, with only half a kilogram of the drug that has a 'disulfiram' like reaction.
The reaction principle of 'disulfiram' is often used in the study of forced abstinence drugs. "Disulfiram" is a kind of alcohol abstaining drug, which has not been approved for production in China. It has been included in Pharmacopoeia of the United States, Japan and other countries as an alcohol abstaining drug. After taking the medicine, the human body has an alcohol metabolism disorder, and the drug users can't and dare not touch a little alcohol, otherwise the body will show the symptoms of 'alcoholism', such as flushing, headache, rapid heartbeat, etc., that is, people who intentionally can drink very much will suddenly feel that the amount of alcohol dropped after taking the medicine. If they drink forcibly, they will be 'Drunk' until 'poisoned'.
The commonly used drugs that contain the similar structure of disulfiram are: cephalosporins [cefoperazone, cefoperazone sulbactam, ceftriaxone, Cefalexin (Xianfeng IV), cefazolin (Xianfeng V), cefradime (Xianfeng VI), Cefmetazole, Cefminox, raoxime, cefepime, cefaclor, etc.],
Among them, cephalosporin induced disulfiram like reaction is the most reported and sensitive. If a patient takes Jiuxin chocolate, Huoxiang Zhengqi water after use, or even only uses alcohol to treat the skin, disulfiram like reaction will occur; nitidazole [such as metronidazole (metronidazole), tinidazole, ornidazole, secnidazole], furan [such as furantoin, furazolidone (litylene), furan After the interaction with alcohol, sulfonamides [sulfonylurea hypoglycemic agents (such as chlorpromazine, tolbutamide, warfarin]; tricyclic psychoactive drugs (such as chlorpromazine, trifluoperazine), tolazolin, insulin, isoniazid, nitroglycerin, Xiaoxintong, diphenhydramine, barbital and other drugs will also produce different degrees of non-interference Good reaction.
Generally use the above drugs, do not drink within one week after drug withdrawal. There was no relationship between the way of administration and the reaction. The reaction was also found in intravenous and oral administration. The main manifestations are chest tightness, suffocation, palpitation, nausea and vomiting. At present, in addition to symptomatic treatment, naloxone is the main drug in the treatment of alcohol withdrawal sulfur like reaction, which can significantly shorten the reaction time.
If cephalosporin antibiotics and metronidazole drugs are used recently, no matter the liquor, beer or wine, no matter the content of alcohol in the liquor or beverage, they should be closed. If any relatives or friends have the above symptoms after drinking alcohol, they should first ask if they have taken the above drugs in the near future, and actively explain to the doctor when going to the doctor, so as not to delay the rescue time. Therefore, in order to avoid the occurrence of disulfide wake-up reaction, they should abstain from drinking during the use of cephalosporin drugs and within one week after stopping the drugs. In addition to not drinking alcohol, you should also avoid taking drugs containing ethanol (such as Huoxiang Zhengqi water, Yangyin Qingfei syrup, etc.), food (such as seasoning, fermented vinegar, Jiuxin chocolate, etc.) and supplements (such as ginseng royal jelly), etc.
If you don't know, don't drink after taking medicine, don't take medicine after drinking!