What medicine can't you take after drinking? Introduction to common sense of taking medicine after drinking
4hw.com.cn: now people are under great pressure in life and have many social gatherings. It is inevitable to drink in social gatherings. Many people even have to drink with illness. Can they take medicine after drinking? What drugs can't you take after drinking? Let's take a look at the common sense of taking medicine after drinking!
Why can't you take medicine after drinking
Alcohol is contained in wine. In addition to accelerating the metabolic transformation of some drugs and reducing the curative effect, ethanol can also induce adverse drug reactions. Long term drinking may cause liver function damage, affect the liver metabolic function of drugs, and increase the adverse reactions of many drugs. Especially when taking medicine, drinking can expand the digestive tract and increase drug absorption, which is easy to cause adverse reactions. If drinking alcohol while taking barbiturates, it can enhance the central inhibitory effect of barbiturates and cause harm. Cephalosporins can affect the metabolism of ethanol, resulting in disulfiram like reactions, such as facial flushing, headache, dizziness, abdominal pain, nausea, vomiting, shortness of breath, accelerated heart rate, decreased blood pressure, drowsiness and hallucination. In addition, some drugs can aggravate the damage of ethanol to human body. For example, ranitidine can reduce gastric juice secretion and aggravate the damage of ethanol to gastric mucosa; Metronidazole can inhibit the activity of acetaldehyde dehydrogenase and aggravate the poisoning reaction of ethanol. Therefore, it is not suitable to drink when taking medicine.
You can't take these drugs after drinking
1. Central depressant
Ethanol can inhibit the central nervous system, and the intensity of the effect is directly proportional to the amount of alcohol. Taking phenobarbital, methylalanine, chlorpromazine and other central nervous system inhibitors after drinking can cause deep inhibition of the central nervous system. Light cases can cause drowsiness, serious cases can cause coma, and even death due to central nervous paralysis.
2. Hypoglycemic drugs
Ethanol can inhibit sugar absorption and gluconeogenesis, and hypoglycemic drugs also mainly act on these links. The synergy of the two will lead to the rapid decline of blood glucose and even hypoglycemic coma. In addition, taking biguanide hypoglycemic drugs such as Jiangtangling after drinking may also cause lactic acidosis.
3. Antihypertensive drugs
Ethanol can dilate blood vessels, inhibit sympathetic nerve and vascular motor center and weaken myocardial contractility. If you take antihypertensive drugs after drinking, it will make small blood vessels more dilated, further reduce blood volume, drop blood pressure suddenly, and appear postural hypotension or syncope.
4. Antipyretic analgesics
Ethanol can secrete a large amount of serum gastrin, and antipyretic analgesics can also increase the secretion of serum gastrin. The combination of the two can cause a sharp increase in the concentration of gastrin and a large amount of gastric acid secretion, so as to destroy the gastric mucosal barrier, damage submucosal blood vessels and cause the risk of gastric bleeding.
5. Cold medicine
Most cold medicines contain acetaminophen (also known as paracetamol), which is used to treat colds, fever and relieve pain. In the process of biotransformation in vivo, acetaminophen will produce a toxic metabolite, which needs to be combined with protective factors such as reduced glutathione in order to reduce the toxicity. Excessive drinking will consume a lot of glutathione in the body, so that the metabolites produced by acetaminophen can not combine with glutathione, increasing the risk of liver failure.
6. Antituberculosis drugs
The oxidation process of ethanol in vivo can produce a large number of free radicals, and the increase of free radicals can damage hepatocytes. Isoniazid and rifampicin anti tuberculosis drugs will increase the liver toxicity of ethanol, cause jaundice and liver function decline.