I will drink for many years when I go home in the new year, but do you know? In fact, I can't take medicine after drinking alcohol, and some drugs will react with alcohol. Now I'll take you to check what medicine I can't take after drinking alcohol?
Disulfiram like reaction, also known as alcohol withdrawal sulfur like reaction, is a toxic reaction of 'acetaldehyde accumulation' in the body caused by drinking alcoholic drinks (or contacting alcohol) after the application of drugs (cephalosporins).
What are its clinical manifestations?
Drinking alcohol (or contact with alcohol) during the medication period is manifested as chest tightness, shortness of breath, laryngeal edema, cyanosis of mouth and lips, dyspnea, increased heart rate, decreased blood pressure, weakness of limbs, flushing on the face, hyperhidrosis, insomnia, headache, nausea, vomiting, dizziness, drowsiness, hallucination, trance, and even anaphylactic shock. The blood pressure drops to 60-70 / 30-40mmhg with loss of consciousness. It is easy to be misdiagnosed as acute coronary syndrome and heart failure. In addition, the severity of disulfiram like reaction was in direct proportion to the dosage of the drug and the amount of drinking alcohol. The reaction of drinking white wine was more serious than that of beer and alcoholic beverages, and the reaction of drinking alcohol during the period of drug use was more serious than that after drug withdrawal.
Which drugs can cause this reaction?
In addition, metronidazole, tinidazole, ketoconazole, furazolidone, chloramphenicol, tolbutamide, glibenclamide, phenformin and so on can cause the disulfiram like reaction.
1. Cephalosporin + alcohol = no alcohol, no tofu, etc
Cephalosporin + alcohol = poison. Alcohol is the main component of wine. Acetaldehyde is produced by digestion in the body. Acetaldehyde needs to be metabolized by enzymes in the liver cells to generate carbon dioxide and water. However, some drugs inhibit the activity of the above metabolizing enzymes, so that acetaldehyde can not be metabolized normally and accumulate in the body, resulting in acetaldehyde poisoning, resulting in a series of poisoning symptoms, which can induce acute liver damage, myocardial infarction, acute heart failure, respiratory failure or even death in serious cases.
2. Paracetamol and cold medicine
Some patients with drunk headache take a small amount of paracetamol to relieve the headache, and there are not a few people who drink during taking cold medicine. Both are very dangerous.
The biggest harm of paracetamol to human body is to stimulate the liver. About 30 paracetamol tablets can kill people at one time. As long as one tablet is taken, it is also an additional burden to the liver. If you drink alcohol while taking paracetamol, it can kill you quickly. At present, there are many anti cold drugs contain paracetamol, even if taking less, but drinking at the same time, drug poisoning may occur.
3. Sedative and hypnotic drugs
For example, brain inhibitors such as phenobarbital, chloral hydrate, diazepam and riminine, under the action of ethanol, will be absorbed by the human body speedily, at the same time, their metabolism speed will be slowed down, and the concentration of drug components in the blood will increase rapidly in a short period of time. After drinking alcohol, the brain central nervous system is excited first and then inhibited by alcohol, so that the normal activities of the central nervous system are severely inhibited, which can cause coma, shock, respiratory failure, death and so on.
4. Antipyretics and analgesics, such as aspirin
This kind of medicine can stimulate and damage the gastric mucosa, while alcohol can also hurt the stomach. The combination of the two can lead to gastritis, gastric ulcer and gastric hemorrhage.
5. Reserpine, anticancer agent, isopharyngitis and other drugs
There are many kinds of wine. If you drink wine after taking this kind of medicine, you are prone to accidents. Because of the tyramine contained in wine, if a large amount of accumulation, it will cause great harm to human body, leading to dizziness, headache, nausea and vomiting, diarrhea, arrhythmia, blood pressure rise and even cerebral hemorrhage. In normal drinking, tyramine can be naturally destroyed by human body, but if the human body can not successfully destroy tyramine after taking this kind of medicine, it will inevitably happen, with serious consequences.
6. Hypertensives
We all know that the occurrence of high blood pressure has a certain connection with daily life habits, such as some bad habits such as smoking and drinking, drinking itself is not terrible, moderate drinking will improve circulation, but if the patients with high blood pressure drink after taking excessive antihypertensive drugs, it will be very dangerous. Because drinking alcohol can dilate blood vessels, enhance the antihypertensive effect of drugs, reduce the normal blood pressure to a lower level, cause sudden hypotension, lead to fainting, falling and other accidents.
7. Antiepileptic drugs
Drinking alcohol can reduce the effect of antiepileptic drugs. This is because ethanol can activate drug metabolism enzymes, accelerate drug metabolism, and reduce drug concentration in the blood.
8. Monoamine oxidase inhibitor
For example, isoniazid, udn, MBH, etc. If the monoamine oxidase inhibitor is taken at the same time of drinking, a large amount of tyramine will be accumulated in the body, a large amount of adrenaline and noradrenaline will be released, resulting in a sudden rise of blood pressure, accompanied by severe headache, vomiting, palpitation, that is, hypertension crisis, which can lead to cerebral hemorrhage in serious cases.
9. Cardiovascular and cerebrovascular drugs
Anti angina drugs, such as Xiaoxintong and nitroglycerin, can rapidly dilate blood vessels. If they are used together with alcohol, the light will aggravate headache, the heavy will cause blood pressure drop, blood lipid rise, gastrointestinal discomfort, and even life-threatening.
10. Hypoglycemic drugs
Alcohol can stimulate the beta; cells in the pancreas and increase the secretion of insulin. If you drink a lot of alcohol during the use of hypoglycemic drugs (youjiangtang, metformin, insulin, etc.), it is easy to have hypoglycemic reaction, dizziness, panic, cold sweat, and can induce Lactatemia.
11. Hepatotoxic drugs
Some drugs have strong hepatotoxicity, and the combination with alcohol will aggravate the liver damage. For example, tetracycline, chloramphenicol, erythromycin, anti tuberculosis drugs (rifampicin), anti-tumor drugs, metal antimony agents, as well as some antipyretic and analgesic drugs, anti schistosomiasis drugs (nithiocyanide), etc.
12. Other anti allergic drugs
Such as cyproheptadine, diphenhydramine, kairuitan, promethazine, chlorpheniramine, etc. These drugs, taken with alcohol, can also inhibit the central nervous system.