Sihai network

Can female menopause eat soybean isoflavone to prevent and treat cardiovascular disease?

Soybean isoflavones play an important role in women's health. Meanwhile, soybean isoflavones are also closely related to cardiovascular and cerebrovascular diseases. Why are women prone to cardiovascular and cerebrovascular diseases when they enter menopause? Can women eat soy isoflavones to prevent cardiovascular and cerebrovascular diseases during menopause?

After entering the climacteric period, the estrogen level is not enough and the secretion of estrogen is insufficient. The decrease of estrogen will lead to the metabolism of fat and cholesterol, which will increase the incidence rate and mortality of cardiovascular disease in menopausal women. According to statistics, the incidence rate of coronary heart disease in menopausal women increased by 2~3 times than that before menopause. The incidence of cardiovascular disease decreased after menopausal women's estrogen replacement therapy (ERT): 35% to 50%. Studies have shown that soy isoflavones with only estrogen activity may play an important role in the pathogenesis of female cardiovascular disease. The results of epidemiological investigation showed that the mortality rate of coronary heart disease in American women aged 40-69 was 8 times higher than that in Japanese women of the same age group. After careful analysis of the data, it was found that the decreasing effect of soy protein on the rate of atherosclerosis may be the main reason for the above mortality difference.

What is soybean isoflavone? Isoflavone is a kind of flavonoids, which mainly exists in leguminous plants. Soybean isoflavone is a kind of secondary metabolites formed in the growth of soybean. Because it is extracted from plants and has a similar structure with estrogen, soybean isoflavone, also known as phytoestrogen, can make up for the deficiency of estrogen secretion in women after 30 years old, improve skin moisture and elasticity, relieve menopausal syndrome and osteoporosis, and make women regain their youthful charm. Soybean isoflavones are natural chemopreventive agents for cancer, which affect hormone secretion, metabolic biological activity, protein synthesis and growth factor activity.

Soybean isoflavones can regulate blood lipid and prevent cardiovascular disease. Heart disease is also a disease related to estrogen. As a phytoestrogen, soybean isoflavones can reduce blood lipid and prevent heart disease

Estrogen like effect promotes thyroxine secretion and bile excretion. It has been fully proved that low density lipoprotein (LDL) cholesterol can be reduced while high density lipoprotein (HDL) cholesterol is not. Isoflavones, as the characteristic of flavonoids, have biological antioxidant effect, which is very important, because the oxidation of low density lipoprotein (LDL) cholesterol is a key factor in the process of atherosclerosis. Women who received 80 mg of genistein per day increased arterial elasticity by about 26%.

Pharmacological effects of soybean isoflavones on cardiovascular system: 1

Soybean isoflavones can improve the symptoms of myocardial ischemia, dilate blood vessels, inhibit platelet aggregation, reduce the content of cholesterol and triglyceride in blood, and have anti arrhythmia effect. In the endocrine system, isoflavones mainly show estrogen like effect, which has dual effects of excitation and inhibition as estrogen. Some isoflavones can also affect bone resorption, so they are beneficial to the treatment of bone diseases.

Therefore, soybean isoflavones can reduce the body's susceptibility to serum LDL oxidation. The oxidation of LDL lipoprotein in serum activates macrophage phagocytosis in the human body and develops into foam cells in the arterial wall to form atheromatous plaques. Soybean isoflavones not only have antioxidant effect, but also can induce the increase of antioxidant enzyme activity, improve the antioxidant activity of serum LDL, prevent the formation of atherosclerotic plaque and prevent atherosclerosis. At the same time, it can increase the compliance of artery and expand the blood vessel. Soybean isoflavones also inhibit the atherosclerosis process by affecting tyrosine kinase, including foam cells, fat streaks, hyperplasia, fibrous plaque infiltration, rupture and ulcers, which maintain smoothly and unimpeded cardiovascular vessels and prevent cardiovascular diseases.

Well, I know so much, sihai.com introduces the preventive and therapeutic effects of soybean isoflavones on the cardiovascular and cerebrovascular system of menopausal women. I hope sihai.com can help women's health!