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What factors lead to coronary heart disease

Coronary heart disease (CHD) is a kind of disease caused by coronary artery stenosis, which leads to ischemia and necrosis of the coronary artery. Do you know what factors are responsible for coronary heart disease?

The main component of coronary atherosclerotic plaque is fat. When the body temperature is 37 ℃, the atherosclerotic plaque rich in fat presents flow or semi flow state. When the vascular segments with atherosclerotic lesions have some changes (relaxation and contraction reaction, temperature change, exertion, inflammation, etc.), the vascular wall surrounding these fatty plaques will rupture and local In case of partial hemorrhage, the body will automatically mobilize the hemostatic system to start working, forming thrombus at the site of vascular rupture (the same as the hemostasis process of hand and foot laceration in daily life). This kind of thrombus formed in the blood vessel for a short time will make the lumen sharply smaller or even completely occluded, which will lead to the obvious reduction or interruption of blood flow in the blood supply area and cause danger. Li Tianchang, Department of Cardiology, Navy General Hospital

In the course of its occurrence and development, there are two main outcomes: one is that the plaque is constantly increasing, resulting in progressive narrowing of the lumen, and finally even occlusion (chronic occlusion); The other is the sudden rupture, hemorrhage and thrombosis in the process of increasing plaque in 20-30 years (generally more than 40 years). The prognosis of the former is generally good, while the latter will cause serious clinical events and consequences. Unfortunately, there is still a lack of means and methods to accurately distinguish the development trend of plaque.