A new study shows that women with congenital heart disease, such as Fallot tetralogy, can carry out normal pregnancy and childbirth, but generally speaking, their abortion rate will increase, and the probability of congenital abnormalities in the next generation will also increase.
Tetralogy of Fallot is a genetic disease with abnormal connection between main arteries and ventricles. It usually needs to be corrected by surgery in childhood.
Gruschen R. veldtman of Mayo Medical Center in Rochester and his colleagues pointed out: 'although some such patients can successfully conceive and deliver, the data are not enough to show that the mother and fetus are absolutely safe in such cases.' The full text of the article was published in the American Journal of Cardiology.
In a review of 72 women with tetralogy of Fallot, the researchers found that 43 women had 112 pregnancies, 82 of which were successful. In eight women, the Fallot tetralogy was not repaired until the successful end of their delivery.
Adverse events in mothers are rare, but if they occur, they are mostly heart related. This was reported in 5-6 cases.
Unrepaired tetralogy of Fallot and pulmonary artery abnormalities are associated with low birth weight.
Although only 1% of the patients had preterm birth, 8.5% of the infants were lighter than the normal weight range, and 6 of the 7 children born from patients with unrepaired tetralogy of Fallot were underweight.
According to medical records, the probability of spontaneous pregnancy failure is 24%, which is 10 percentage points higher than that of the normal population. The incidence of congenital defects including congenital heart disease and gastric outlet obstruction was 6%, twice that of normal infants.
In an article in the journal, John S. child commented that this study once again confirmed that women who successfully repaired the tetralogy of Fallot were at low risk of fertility, but did not rule out individual cases.
However, the view from the ahmanson UCLA adult congenital heart disease center is that although the success rate of pregnancy and delivery is high, the rate of congenital defects in infants also increases. Babies born are also more likely to develop other diseases as they grow older.