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The man died three days after receiving rabies vaccine, and the drug administration has sent the vac

Original title: a 29 year old man died three days after injection of rabies vaccine. Suzhou food and drug administration has sent the vaccine for examination

In early April this year, a 29 year old man died three days after receiving rabies vaccine in Suzhou, Jiangsu Province.

Surging news reporters learned from their families that Wang Xinwei (a pseudonym) who worked in Suzhou on April 4 this year was scratched by a domestic vaccinated kitten; On April 5, Wang Xinwei injected rabies vaccine in the outpatient department of Caohu people's Hospital, Xiangcheng District, Suzhou. In the next two days, Wang Xinwei had chest pain, body pain, fever, diarrhea and low blood pressure.

On April 8, Wang Xinwei was unconscious and lost spontaneous breathing. He was sent to the First Affiliated Hospital of Suzhou University for first aid. Finally, he suffered from systemic organ failure and died at about 5:30 p.m. that day.

The surging news reporter learned that Wang Xinwei injected the freeze-dried human rabies vaccine produced by Liaoning Chengda biology Co., Ltd., the production date is May 5, 2018, the validity period is May 4, 2021, and the batch number is 201805102. Liaoning Chengda is currently the largest domestic rabies vaccine manufacturer in China.

After the incident, the family members reported the above situation to the local regulatory authorities. On May 21, the staff of Suzhou food and drug administration went to Caohu people's Hospital of Xiangcheng District to seal up the remaining two vaccines of Wang Xinwei, and the remaining 13 vaccines of the same batch were also sealed up. It is understood that these vaccines will be sent to Beijing for testing.

Wang Xinwei's wife Zhang Jie (pseudonym) told surging news reporters that her husband's sudden death has been unacceptable to her and her family. Wang Xinwei is only 29 years old. According to the physical examination report in February this year, his physical condition is not abnormal.

Zhang Jie suspected that there was a problem with the injected vaccine. The reason for this is that after Wang Xinwei had discomfort symptoms such as chest pain and diarrhea, he went to the emergency department of Caohu people's hospital. The inspection report showed that Wang Xinwei had allergic diarrhea.

"After seeing this checklist, I told the doctor that he had been vaccinated against rabies on the 5th, and the doctor denied that it was a vaccine problem." Zhang Jie told reporters.

At about 7 a.m. on April 8, seeing that my husband was not getting better, Caohu people's Hospital suggested that we transfer to a larger Xiangcheng people's hospital. Xiangcheng people's hospital gave the diagnosis of suspected cardiac dissection. The hospital suggested that if we want better surgical treatment, we should go to the First Affiliated Hospital of Suzhou University. After arriving at the First Affiliated Hospital of Suzhou University at about 10 a.m. on April 8. The hospital issued a critical notice. " Zhang Jie recalled the treatment scene at that time.

A critical notice provided by Zhang Jie from the First Affiliated Hospital of Suzhou University shows that Wang Xinwei's clinical diagnosis is suspected of septic shock and aortic dissection.

According to Zhang Jie, the diagnosis of Caohu people's hospital was allergic diarrhea; Xiangcheng people's Hospital considers it as cardiac dissection and gives two options of conservative treatment or operation; The doctors of the First Affiliated Hospital of Suzhou University denied the cardiac dissection and suspected that it was an explosive blood disease.

"This is most likely due to allergic reactions to rabies vaccine." Zhang Jie said, 'and it is impossible to have an outbreak of rabies within three days. We think it is organ failure caused by allergic reaction. But until my husband died, the hospital did not give the specific reason for our death. "

On May 24, the surging news reporter consulted the staff of the medical department of Liaoning Chengda biology Co., Ltd. about the vaccine allergy. The other party said that the usual clinical manifestations of vaccine allergy are Henoch Schonlein purpura, red rash or bleeding points under the skin. The staff member also said that diarrhea is also possible, but it is not caused by allergy, but the intestinal disorder caused by the stress response of the immune system to the vaccine.

The staff member said that the rabies vaccine is an inactivated vaccine, which is the same as the allergic symptoms that may be caused by all inactivated vaccines. There is no need to worry too much about safety. Even if there is an allergy, it will not be a big problem.

Surging news reporters verified Wang Xinwei's deathbed with the First Affiliated Hospital of Suzhou University. The staff in charge of answering the phone in the outpatient department of the hospital said that due to the long time interval and many patients, they were unable to give a reply.

Wang yuedan, deputy director of the Department of immunology of Peking University, pointed out to the surging news reporter that whether it is caused by the vaccine needs to wait for the verification results given by the drug regulatory department. " However, from the description, there are no typical allergic symptoms, but mainly gastrointestinal symptoms. This is not a common situation in the process of rabies vaccination, and there are no autopsy and pathological anatomy results. From the current situation, it is difficult to say that it is caused by the vaccine. " Wang yuedan said.

Earlier, after the death of Lianyungang girls after vaccination was exposed, vaccine manufacturers told surging journalists that the situation of girls was a coincidence.

For Wang Xinwei's death, Wang yuedan also analyzed that the possibility of coincidence cannot be ruled out. " It depends on the specific situation, such as his previous health status and whether he takes other drugs. How many degrees of fever he has after vaccination is also a relevant consideration. Of course, it may also be because he is in the early stage of infection before vaccination, such as virus infection. "

Wang yuedan also said: "it is sometimes difficult to find some organic diseases, such as cardiovascular diseases, in ordinary physical examination. From his symptoms, there are some symptoms of cardiovascular diseases, such as chest pain and low blood pressure, so I don't think it is much like allergic reaction. It may be like myocarditis virus infection, but I can't be sure yet, Nor can it establish a relationship with the vaccine. "

As of press time, surging journalists could not contact Suzhou drug administration to explain the incident.

The staff of the president's office of Caohu people's Hospital in Xiangcheng District, where Wang Xinwei visited, told reporters that when the patient came to the hospital, he was determined to have intestinal infection. It was unclear whether the patient had used other sensitizing foods before. The staff also stressed that the hospital had not encountered a similar situation before.

In the case of fever and death of Lianyungang girls after rabies vaccine injection previously reported by surging news, the products injected by girls were freeze-dried rabies vaccine for human use produced by Guangzhou nuocheng.

On April 26 this year, the girl was scratched by a pet dog on her right finger. About 23 hours later, at 15:55 on April 27, the girl injected the first rabies vaccine in the second people's Hospital of Ganyu District, Lianyungang City. At that time, the medical staff told that the children might have fever after vaccination. At about 22:00 on April 27, the girl had fever; Fever again after taking medicine; In the early morning of April 28, the family took the girl to Ganyu District People's Hospital for emergency treatment; In the morning, he was referred to Lianyungang first people's Hospital; At about 16:00 on the same day, the girl died after rescue.

Tao Lina, a popular science writer and vaccine expert, said that according to the test data at home and abroad, about 35% - 45% of people will have slight rash, pain or swelling at the vaccination site after vaccination; 5% - 15% of people will have slight systemic adverse reactions such as fever, headache, dizziness and gastrointestinal symptoms.

However, Tao Lina also pointed out that rabies vaccine is an inactivated vaccine, which does not contain live microorganisms and will not cause vaccinators to be infected with rabies.

Attachment: timeline from Wang Xinwei's visit to his death

At about 10:00 p.m. on April 4, 2019, he was scratched by a vaccinated cat;

At about 10 a.m. on April 5, 2019, he went to the outpatient department of Caohu people's Hospital in Xiangcheng District to inject rabies vaccine;

On the afternoon of April 5, 2019, he began to feel sore and accompanied by fever;

On the morning of April 6, 2019, I went to Caohu people's Hospital in Xiangcheng District to consult a doctor. The doctor told me that it was normal and that I could take some antipyretic drugs;

On the evening of April 6, 2019, diarrhea began and lasted all night;

At about 8 p.m. on April 7, 2019, I went to the emergency department of Caohu people's Hospital in Xiangcheng District and felt chest tightness, hypothermia and low blood pressure;

At about 7 a.m. on April 8, 2019, Caohu people's Hospital of Xiangcheng District suggested going to Xiangcheng District People's Hospital for treatment

Before 8:00 a.m. on April 8, 2019, the patient arrived at Xiangcheng people's hospital. The patient developed chest pain, and the doctor gave the diagnosis of suspected cardiac dissection.

At about 10 a.m. on April 8, 2019, after arriving at the First Affiliated Hospital of Suzhou University, the doctor denied the diagnosis of cardiac dissection and suspected that it was explosive blood disease;

He died around 5:30 p.m. on April 8, 2019.