What are the side effects and contraindications of Angelica dahurica
4hw.org: we all know that Angelica dahurica is a very famous Chinese herbal medicine, which can dispel wind and relieve pain, and also can refresh the mind. It has a significant effect on many diseases. Today, Xiaobian will talk with you about angelica, a traditional Chinese herbal medicine, to see how it works. Let's have a look.
What is Angelica dahurica
Angelica dahurica is a kind of perennial herb, which is fragrant and white in taste. It is one of the traditional Chinese medicinal materials in China. Angelica dahurica is a tall perennial herb with a height of 1-2.5m, a cylindrical root, a diameter of 2-5cm at the base of the stem, a pinnate division of the basal leaves, a terminal or lateral compound umbel, and a round to oval fruit.
With root as medicine, it has the functions of removing diseases and dampness, discharging pus and generating muscle, promoting blood circulation and relieving pain. Indications: cold, headache, rhinitis, toothache. It can also be used as perfume. Some provinces and regions in the north have cultivation, most of which are self-produced and sold, and a few of which are outside the province. It is generally found under the forest, at the edge of the forest, beside the stream, in the Bush and in the valley grassland.
Sexual taste, sexual temperature, pungent taste, fragrant air, slightly bitter. The root is cone-shaped, 10-20cm long and 2-2.5cm in diameter. The surface is grayish brown, with lateral protuberant lenticels and sunken stem marks on the top. It is hard, white in cross section, powdery enough, and the skin is densely covered with brown oil spots.
II. Effect and function of Angelica dahurica
The effect of Angelica dahurica
1. The traditional efficacy of Angelica dahurica is to dispel wind, dry dampness, detumescence and relieve pain. It is usually used to treat headache, bone pain, toothache, abdominal pain, dry and itchy skin and other problems. Angelica dahurica is a unique medicinal material of Wushan, a famous analgesic, which has been gradually applied throughout the country.
2. Angelica dahurica can stimulate the central nervous system and improve the spirit. However, we need to pay attention to the dosage. A small amount can excite the central nervous system, such as the motor center, respiratory center and spinal system. However, if the dosage is large, it is easy to cause spasm, paralysis and so on. We need to pay attention to the dosage.
3. Relieve pain through orifices. Su Shi, the great poet, once had a headache and a stuffy nose. Later, a monk brought a package of medicinal materials to him for decoction. Unexpectedly, it was able to pass through the nose and make people feel fresh. It turned out that this pair of medicine was Angelica dahurica, also known as "fragrant Angelica" and "hang Angelica".
4. Angelica can also reduce blood pressure. Angelica contains isoimperatorin and Indian quince, which can reduce blood pressure. In addition, it has antibacterial and anti-inflammatory effects.
5. Angelica dahurica has the effects of inhibiting fat synthesis, relieving fever and pain, hemostasis, antiasthmatic, etc.
6. Treatment of dysmenorrhea. It is said that in the Northern Song Dynasty, there was a rich merchant's daughter who suffered from painful menstruation every time. Her body was getting weaker and weaker. The rich merchant was very anxious. She was going to take her daughter to the capital city to find a famous doctor for diagnosis and treatment. Later, she met an old man of herbal medicine. After finding out the situation, she took a present of Angelica dahurica from her medicine basket and gave it to him for decoction. I didn't expect to drink it several times, but the medicine can get rid of the disease. This mainly shows that Angelica dahurica has the effect of treating dysmenorrhea.
7. Angelica dahurica can treat skin problems. For example, Angelica dahurica contains' photoactive substances', such as vanillin, zanthoxylin and isoimperatorin, which can effectively treat vitiligo; Angelica dahurica can also inhibit the occurrence of dermatitis.
8. Dispel wind and cold. Angelica dahurica can treat cold, headache, rhinitis and toothache caused by cold.
9. Promote blood circulation and discharge pus for swelling and pain of sore. For example, if the primary mastitis can be used together with dandelion and Trichosanthes, if the pus is not smooth, it can be used together with honeysuckle and smallpox powder.
10. Generate muscle and relieve pain. Angelica dahurica for lumbar muscle strain, muscle pain has the effect of eliminating blood stasis, promoting muscle inflammation and pain.
11. Dry and damp tourniquet. Angelica dahurica is mainly used to treat cold and damp leucorrhea. It is often used in combination with cuttlebone. If it is in the wet tropics, it can also be used in combination with heat clearing and damp drying drugs such as phellodendron and toon root bark.
The function of Angelica dahurica
1. Anti inflammatory effect
Angelica dahurica or hangbaizhi Decoction (LG is the same as the crude drug LG) 4G / kg can significantly inhibit xylene induced ear inflammation in mice (P & lt; 0.01).
2. Antipyretic and analgesic effects
The animal model of high fever was made by subcutaneous injection of peptone into the back of the big white rabbit. 1 g of Angelica dahurica or hang Baizhi Decoction 15 g / kg had obvious antipyretic effect. The mice were given 8 g / kg of Angelica dahurica or hangbaizhi Decoction by gavage, which significantly reduced the number of writhing induced by intraperitoneal injection of 1% acetic acid (0.l / kg), similar to aminopyrine 8 mg / kg, P & lt; 0.001. In the hot plate test of mice, if the pain threshold was less than 30 minutes before administration, 8 g / kg of Angelica dahurica or dahurica dahurica was given by gavage. 60 minutes after administration, the pain threshold of Angelica dahurica and anti Angelica dahurica increased significantly, P & lt; 0.001 and 0.01 compared with the normal saline group.
3. Antispasmodic effect
The contents of bergamot lactone, zanthoxylin and isoimperatorin have obvious antispasmodic effect on ileum of rabbits. Isoimperatorin can also increase the contractility of rabbit uterus and the tension of earthworm muscle. Scopolamine has an antispasmodic effect on in vivo or in vitro uterine spasm induced by estrogen or barium chloride, and its ED50 is 0.09mg/kg.
4. Effect on cardiovascular system
Isoimperatorin and indosinin contained in the product can reduce blood pressure in cats. 50mg / kg can reduce arterial pressure by 50%, and the duration of action is 1.5h. The copolymer of isoimperatorin and N-vinylpyrrolidone can prolong the time of arterial pressure reduction by 5-10 times. It can also reduce the contractility of isolated frog heart.
5. Antibacterial effect
Angelica dahurica decoction can inhibit Escherichia coli, dysentery, proteus, typhoid, paratyphoid, Pseudomonas aeruginosa, Vibrio cholerae, human tuberculosis and so on.
The results showed that the oxy imperatorin contained in the product had antibacterial effect on 11 strains in vitro; the oxyimperatorin also had antibacterial effect on zanthoxylin; the MIC of the product to human tuberculosis H37Rv was 100mcg / ml. The aqueous extract also had a certain inhibitory effect on the pathogenic fungi such as tinea Micrococcus.
6. Photosensitivity
The citronellactone, zanthoxylin, isoimperatorin and other furan coumarin compounds contained in the product are photoactive substances. When they enter the body, once they are exposed to sunlight or ultraviolet light, they can cause sun dermatitis, redness, pigmentation and pigmentation thickening of the irradiated skin.
The most photosensitive activity was zanthoxylin, citrus lactone and isoimperatorin B. Photosensitive active substances can be used to treat vitiligo. Isoimperatorin is an effective component in the treatment of psoriasis, which is proved to be effective by the measurement of erythema.
7. Anticancer effect
Isoimperatorin and Angelin have cytotoxic effects on HeLa cells. ED50 100 & mu; g / ml of isoimperatorin.
8. Radiation resistance
Angelica dahurica methanol extract 1g / kg was injected intraperitoneally 5 minutes before X-ray irradiation, which had protective effect on skin damage of mice.
9. Antihypertensive effect
Angelica dahurica contains isoimperatorin and Indian quince, which can reduce blood pressure in cats for 1.5 hours.
10. Other functions
A small amount of Angelica dahurica venom can excite the vasomotor center, respiratory center, vagus nerve and spinal cord of the medulla oblongata. It can increase the blood pressure, slow the pulse, deepen the respiration, cause salivation and vomiting. A large amount of use can cause tonic intermittent spasm, followed by general paralysis.
Clinical report: modern external use of this product is effective in the treatment of hydroarthrosis, herpes zoster, psoriasis and other diseases.
3. Side effects of Angelica dahurica
After years of research, it has been proved that Angelica dahurica has many effects, but the corresponding Angelica dahurica has some side effects. For example, Angelica dahurica can excite the central nervous system, but if the dosage is too large, it is easy to cause general spasm and paralysis convulsion.
Secondly, angelica has a photosensitive effect, can absorb a certain amount of ultraviolet light, too much sun can easily cause skin blackening; moreover, not all people are suitable for taking angelica, such as those people who are yin deficiency and blood heat are not suitable for taking angelica.
IV. drug contraindications of Angelica dahurica
(1) do not take Yin deficiency and blood heat.
(2) Bencao Jingshu: vomiting is forbidden because of fire. Do not use if it is caused by red, white, yin deficiency, fire and blood heat. If the carbuncle has already collapsed, it should be gradually reduced.
Identify
(1) take 0.5g powder of this product, add 3ml of ether, shake it for 5min, leave it for 20min, take 1ml of supernatant, add 2-3 drops of 7% hydroxylamine hydrochloride methanol solution and 20% potassium hydroxide methanol solution respectively, shake it well, put it on the water bath for slight heat, cool it, add diluted hydrochloric acid to adjust the pH value to 3-4, add 1-2 drops of 1% ferric chloride ethanol solution, purplish red.
(2) take 0.5g powder, add 3ml water, shake and filter. Take 2 drops of the filtrate, dot it on the filter paper, place it under the ultraviolet light (365 nm), and observe it, showing blue fluorescence.
(3) take 0.5g powder of this product, add 10ml of ether, soak it for 1h, shake it constantly, filter it, evaporate the ether from the filtrate, add 1ml of ethyl acetate to the residue to dissolve it as the test solution; take the control sample of imperatorin and isoimperatorin, add ethyl acetate to make a mixed solution containing 1mg of each 1ml as the control solution.
According to the test of thin layer chromatography (Appendix Ⅵ b), take 4ml of each of the above two solutions, place them on the same silica gel G thin layer plate with sodium carboxymethylcellulose as the binder, develop them under 25 ℃ with petroleum ether (30-60 ℃) - ether (3:2), take them out, dry them in the air, and inspect them under ultraviolet light (365 nm).
In the chromatogram of the test sample, fluorescent spots of the same color are displayed at the corresponding positions of the chromatogram of the reference sample.