Which medicine should not be taken after drinking? How long can I take it after drinking
4hw.org: with the increasing pressure of modern people, it's inevitable for people to drink at social gatherings. Many people even have to drink with illness. Can they take medicine after drinking? Which drugs can't be taken after drinking? Let's learn about it!
Why can't I take medicine after drinking
Alcohol is in the wine. In addition to accelerating the metabolism of some drugs in vivo and reducing the efficacy, ethanol can also induce adverse drug reactions. Long term drinking may cause liver function damage, affect the metabolism function of liver to drugs, and increase the adverse reactions of many drugs. Especially when taking medicine, drinking alcohol can expand the digestive tract and increase drug absorption, which is easy to cause adverse reactions. If drinking alcohol while taking barbiturates, it can enhance the central inhibition of barbiturates and cause harm. Cephalosporin antibiotics can affect the metabolism of ethanol, and the reaction of disulfiram is manifested as facial flush, headache, dizziness, abdominal pain, nausea, vomiting, shortness of breath, acceleration of heart rate, reduction of blood pressure, drowsiness and hallucination. In addition, some drugs can aggravate the damage of alcohol to human body. For example, ranitidine can reduce the secretion of gastric juice and aggravate the damage of ethanol to gastric mucosa; metronidazole can inhibit the activity of aldehyde dehydrogenase and aggravate the toxic reaction of ethanol. Therefore, it is not suitable to drink alcohol when taking medicine.
You can't take these drugs after drinking
1. Central depressant
Ethanol can inhibit the central nervous system, and the intensity of action is proportional to the amount of alcohol. After drinking alcohol, people take phenobarbital, methylalanine ester, chlorpromazine and other central nervous depressants, which can make the central nervous system produce deep inhibition. The light ones cause people to fall asleep, the heavy ones cause coma, and even death due to central nervous paralysis.
2. Hypoglycemic drugs
Ethanol can inhibit the absorption of glucose and gluconeogenesis, and hypoglycemic drugs also play an important role in these processes. The combination of the two will cause the blood sugar to drop too fast and even lead to hypoglycemia coma. In addition, taking hypoglycemic drugs such as Jiangtangling after drinking may also cause lactic acid poisoning.
3. Antihypertensive drugs
Ethanol can dilate blood vessels, inhibit sympathetic nerve and vasomotor center, and weaken myocardial contractility. If you take antihypertensive drugs after drinking, it will make small blood vessels more dilated, blood volume further reduced, blood pressure plummeted, postural hypotension or fainting will occur.
4. Antipyretic and analgesic
Ethanol can make a large amount of serum gastrin secretion, antipyretic analgesics can also increase the serum gastrin secretion, the combination of the two can cause a sharp increase in the concentration of gastrin, a large amount of gastric acid secretion, so as to damage the gastric mucosal barrier, damage the submucosal blood vessels, and cause the risk of gastric bleeding.
5. Cold medicine
Most cold medicines contain paracetamol (also known as paracetamol), which is used to treat cold, fever and relieve pain. In the process of biotransformation, acetaminophen will produce a kind of toxic metabolite, which needs to be combined with glutathione and other protective factors to reduce the toxicity. Excessive drinking will consume a lot of glutathione in the body, so that the metabolites produced by acetaminophen cannot combine with glutathione, which increases the risk of liver failure.
6. Antituberculotics
The oxidation process of ethanol in vivo can produce a lot of free radicals, and the increase of free radicals can damage hepatocytes. Isoniazid, rifampicin and other antituberculosis drugs can increase the liver toxicity of ethanol, cause jaundice and liver function decline.