Cleft lip and jaw is a common congenital defect, which occurs in at least one out of every 1000 babies born in the UK. What causes cleft lip? As we all know, the daughter of Li Yapeng and Wang Fei is cleft lip. Li Yapeng founded Yan Ran foundation to help more unfortunate families!
This occurred in the early stage of pregnancy when the upper jawbone of the fetal mouth failed to properly engage. Infants with cleft lip need to undergo multiple operations, as well as language therapy, to remedy the congenital defect. The disease also has a lot to do with genes. If a baby's brother or sister also has this congenital defect, the baby is 30 to 40 times more likely to have this defect than other babies.
Pathogeny:
The causes of cleft lip and palate have not been fully understood, but may be related to the following factors:
① genetic factors: genetic research shows that the disease is a polygenic genetic disease, 20-30% of patients have positive genetic factors. We often see similar deformities in relatives of patients.
② environmental factors: such as the lack of vitamin during pregnancy, the mother's infection with virus during pregnancy, exposure to X-ray, hormone or anti-tumor drugs, antihistamines, tobacco and alcohol stimulation, etc., may cause a series of genetic mutations and other aberrations.
In conclusion, teratogenic factors are various, but not very clear, which can be simply considered as a polygenic genetic disease.