Psoriasis is a kind of skin disease. It is a common chronic skin inflammation, but it is different from other skin inflammation. We all want to know the causes of psoriasis, but the pathogenesis of psoriasis is more complex. At present, it can only be said that it is caused by the comprehensive action of a series of external factors. Let's talk about the common factors leading to psoriasis. Let's have a look.
1. Infection factors
Although infection is not the direct cause of psoriasis, a considerable number of patients will have a history of acute tonsillitis, otitis media, cold and other infections before the onset of psoriasis. This may be because the body is in a stress state after infection and fever and is susceptible to other pathogenic factors, or the antigenicity of metabolites (endotoxin, etc.) after infection changes the immune state of the body, activates psoriasis related genes in the body, and causes skin damage.
2. Genetic factors
Psoriasis has a certain genetic tendency. Patients often have a family history. Psoriasis may occur in several consecutive generations or many people in the same generation. At present, it is considered that psoriasis is a polygenic genetic disease. People with psoriasis genetic background are more likely to be infected by various pathogenic factors. However, many problems such as how to inherit psoriasis and how many genetic genes have not been studied.
3. Environmental factors
The number of psoriasis caused by the invasion of wind and cold is more. Due to the humid living environment and cold weather, the disease can occur or aggravate. Therefore, patients should try to avoid the stimulation of skin by cold and heat, and keep the living room ventilated and dry.
4. Immune factors
The cellular immune function of patients with psoriasis is disordered, with abnormal expression of a variety of fine brain factors and immune types. The serum immunoglobulin IgA and IgE are high and IgM is low. Many factors leading to psoriasis are caused by interfering with the immune function of the body
5. Endocrine factors
The human endocrine system is a huge and complex system, which regulates normal physiological functions by producing a variety of hormones. The disorder of endocrine function is also closely related to the pathogenesis of psoriasis, including the differences of sex hormones, prostaglandins, thyroxine, corticosteroids and other abnormalities.
6. Other factors
There are many reasons for psoriasis, such as the reaction of some drugs taken, mental tension and anxiety, seasonal climate, trauma, overeating, smoking and drinking, which can play a role in the pathogenesis of psoriasis.