Why can't you drink when you eat cephalosporin?
4hw.com.cn: I believe many friends have heard such jokes: say wine and go. We know that you can't drink when eating cephalosporin. When seeing a doctor in the hospital, the doctor will also care about whether the patient drinks. Why can't you drink when eating cephalosporin? What are the consequences of eating cephalosporin and drinking? Let's have a look.
After alcohol enters the human body, it needs to be oxidized and metabolized by two enzymes. First, it is oxidized to acetaldehyde by ethanol dehydrogenase, and then acetaldehyde is oxidized and decomposed into water by acetaldehyde dehydrogenase. Research and analysis: cephalosporins are easy to produce 'disulfiram' reaction when combined with alcohol. In short, cephalosporins inhibit acetaldehyde dehydrogenase in the liver. This enzyme is very important for people who drink. A high level of enzyme means strong anti alcohol function. Once the enzyme function is inhibited, alcohol (ethanol) can no longer be oxidized and decomposed after being oxidized to acetaldehyde in the human body, resulting in acetaldehyde accumulation in the body and acetaldehyde poisoning reaction. Clinical studies have found that the reaction generally occurs 8 to 10 minutes after drinking, sometimes only 20 seconds later, and also after the slowest hour. Its severity is directly proportional to the amount of drug and alcohol consumption. If it is a person who does not drink or has a small amount of alcohol, the reaction is more serious. The reaction after intravenous medication will be faster and more serious than oral medication. The main manifestations are facial fever, flushing, blurred vision, headache, nausea and vomiting, tachycardia, decreased blood pressure, irritability, etc.
For disulfiram reaction symptoms, if they appear quickly, they will ease and disappear quickly. Generally, they can ease themselves after rest adjustment; If there are serious symptoms such as respiratory depression, myocardial infarction and acute heart failure, they must be sent to the hospital for symptomatic treatment immediately, and promote ethanol metabolism and excretion as soon as possible. If they are not treated in time, they may lead to shock or even death.
A person with a capacity of 1 kg of alcohol can have serious problems, including death, in only half a Liang after taking the drug with 'disulfiram' like reaction.
The principle of 'disulfiram' reaction is often used in the study of forced abstinence drugs. " Disulfiram 'was originally an alcohol abstinence drug, which was not approved for production in China. As an alcohol abstinence drug, it has been included in the Pharmacopoeia of the United States, Japan and other countries. After taking the drug, the human body has alcohol metabolism disorder, and the drug taker can't and dare not touch a little alcohol, otherwise the body will have flushing, headache, fast heartbeat and other similar manifestations of 'alcoholism', that is, people who are very able to drink deliberately will suddenly feel that their alcohol consumption has decreased after taking the drug. If they drink it forcibly, they will be 'Drunk' until 'poisoning'.
Common drugs containing disulfiram like drugs include: cephalosporins [cefoperazone, cefoperazone sulbactam, ceftriaxone, Cefalexin (Pioneer IV), cefazolin (Pioneer V), Cefradine (Pioneer VI), Cefmetazole, Cefminox, cefotaxime, cefmendo, cefaclor, etc,
Among them, the reports of disulfiram like reaction caused by cefoperazone are the most and sensitive. Disulfiram like reaction will occur if patients eat wine heart chocolate, take Huoxiang Zhengqi water, or even treat their skin with alcohol only; Nitroimidazoles [such as metronidazole (metronidazole), tinidazole, ornidazole, secnidazole], furans [such as furantoin, furazolinone (dysteryl), furacilin, chloramphenicol, ketoconazole, griseofulvin]; Sulfonamides [sulfonylurea hypoglycemic drugs (such as chlorsulfopropylurea, tolbutamide), warfarin]; Tricyclic psychotropic drugs (such as chlorpromazine, trifluoperazine), tolazurin, insulin, isoniazid, nitroglycerin, indomethacin, diphenhydramine, barbiturates and other drugs will also produce different degrees of adverse reactions after interacting with alcohol.
Generally use the above drugs, and do not drink alcohol within one week after stopping the drugs. There was no relationship between the route of administration and the reaction, and there were also reactions in intravenous and oral administration. The main manifestations are chest tightness, suffocation, palpitation, nausea and vomiting. At present, in addition to symptomatic treatment, the main drug for the treatment of sulfur like reaction in abstinence is naloxone, which can significantly shorten the reaction time.
If the cephalosporins and metronidazole are used recently, whether liquor, beer or wine, Baijiu and alcoholic beverages, regardless of the size of their products, they must be closed. If relatives and friends have the above symptoms after drinking, they should first ask whether they have taken the above drugs recently, and take the initiative to explain to the doctor when seeking medical treatment, so as not to delay the rescue time. Therefore, in order to avoid the occurrence of disulfide wake-up reaction, they should avoid alcohol during the use of cephalosporins and within one week after drug withdrawal. In addition to not drinking alcohol, you should also avoid taking drugs containing ethanol (such as Huoxiang Zhengqi water, Yangyin Qingfei syrup, etc.), food (such as seasoning agent, fermented vinegar, wine heart chocolate, etc.) and supplements (such as ginseng royal jelly).
If you don't know, don't drink after taking drugs, and don't take drugs after drinking!