Pregnant woman weight is very heavy, how to do namely adiposity does not come down? Overweight or obesity in early pregnancy is associated with an increased risk of cerebral palsy in full-term children.
Eduardo Villamor, a researcher at the University of Michigan, said the Swedish national study found that increased maternal overweight and obesity were associated with the incidence of cerebral palsy in offspring. This association is limited to full-term children, partly due to asphyxia related neonatal complications.
Despite improvements in perinatal care, the report shows an increase in the incidence of cerebral palsy among full-term children born between 1998 and 2006. Maternal obesity is a risk factor for obstetric complications and neonatal asphyxia related complications. Whether this factor affects the risk of cerebral palsy in offspring remains unclear.
Therefore, Villamor and colleagues explored the correlation between obesity in early pregnancy and the risk of cerebral palsy in offspring, and any relevant mechanism. Using Swedish medical birth record data from 1997 to 2011, the researchers conducted a national retrospective cohort study of 1423929 singletons. At the same time, the researchers sorted out the national registration records of diagnosis of children with cerebral palsy in 2012.
Overall, during a median follow-up of 7.8 years, 3029 children were diagnosed with cerebral palsy.
The researchers also found that overweight (BMI between 25 and 29.9) and increased obesity (BMI & Ge; 30) in early pregnancy were associated with increased incidence of cerebral palsy in offspring. This correlation was only statistically significant in full-term children (about 71% of all children with cerebral palsy).
Compared with the normal weight children, the adjusted risk ratio of children with overweight (1.22), grade 1 obesity (1.28), grade 2 obesity (1.54) and grade 3 obesity (2.02) increased gradually.
The researchers also found that about 45% of the previous correlation between maternal BMI and the incidence of cerebral palsy in term infants was mediated by neonatal complications associated with birth asphyxia.
Although maternal obesity seems to have less impact on the risk of cerebral palsy in offspring than other risk factors, the authors emphasize that the obesity rate is increasing. In the United States alone, about half of pregnant women are overweight or obese at the time of their first prenatal examination. Considering the high incidence rate of obesity, the dose response relationship between overweight and obesity and the incidence of cerebral palsy in offspring may have a serious impact on public health.